RGPV / RGTU PY-203 PHARMACEUTICAL CHEMISTRY-III ( ORGANIC-I ) SYLLABUS

RGPV / RGTU B. PHARMACY PHARMACEUTICAL CHEMISTRY-III PY-203 (ORGANIC-I) SYLLABUS

UNIT-I

Structure and Properties: Electronegativity, Polarity, Resonance;Electrophiles/Nucleophiles, Orbitals, π-Bonds, Hybridization and Shape, Isomerism, Polarity, Intermolecular Forces, isotope effects and isotopic labelling.

UNIT-II
Reactive Intermediates: Stability and reactivity of Radicals, Cations, Anions, Nitrene and Nitrenium ion

UNIT-III

Stereochemistry: Stereo-isomerism, classification and Nomenclature, Optical activity, Chirality, R/S Classification of Chiral Carbons. Miscellaneous Stereochemistry, Diastereomers; Racimic modification, Resolution of racimic mixtures.

UNIT IV
Hydrocarbons: Alkanes and cycloalkanes:Nomenclature, Physical and chemical properties of alkanes, Conformations and Stability of Acyclic Alkanes and Cycloalkanes. Alkenes and alkynes: Nomenclature, Physical and Chemical properties of alkenes, isomerism, and general methods of preparation.Aromatic hydrocarbons:Benzene and its homologues (Polynuclear compounds),nomenclature, sources of aromatic hydrocarbons, structure of benzene, chemical reaction of benzyne-mechanism and SNAr Mechanism of nucleophilic substitution. Directive influence of substituents and their effect on reactivity. Dienes and the Allyl system: Conjugation, Reactivity.

UNIT-V

Organic compounds with functional groups containing halogens (X): Nomenclature, Structure, Properties, Reactivity of Alkyl Halides (haloalkanes and haloarenes): The SN2 and SN1 Substitution Reaction, The E1 and E2 Elimination Reactions, Substitution vs. Elimination reaction, reactivity of C-X bond in haloalkanes and haloarenes

UNIT VI
Organic compounds with functional groups containing oxygen (Part I-): Alcohols: Nomenclature, Synthesis, reactivity of different Alcohols; conversion of Alcohols to Tosylates or Halides.Phenols: Nomenclature, methods of preparation, physical and chemical properties; chemical reactivity of phenols in electrophilic substitutions, acidic nature of phenol. Ethers: electronic structure, structure of functional group, nomenclature,important methods of preparation, physical and chemical properties, some commercially important compounds.

UNIT-VII

Organic compounds with functional groups containing oxygen (Part II): Aldehydes and ketones : Electronic structure of carbonyl group, nomenclature, important methods of preparation, physical properties and chemical reactions, relative reactivity of aldehydic and ketonic groups, aldol condensation. nucleophilic addition reaction to >C=O groups.
Carboxylic acids: Electronic structure of -COOH, Nomenclature, important methods of preparation, physical properties and effect of substituents on α-carbon on acid strength, chemical reactions.Derivatives of carboxylic acids: Electronic structure of acid chloride, acid anhydride, ester and amide groups, Nomenclature, important methods of preparation, comparative reactivity of acid derivatives.

UNIT-VIII
Organic Compounds with functional group containing Nitrogen: Structure, Nomenclature of Amino and Diazo Compounds.Amines: Primary, secondary and tertiary amines, a general awareness, important methods of preparation, physical properties, basic character of amines, chemical reactions.Diazonium salts:Preparation, chemical reaction and uses of Benzene diazonium chloride. Some commercially important nitrogen containing carbon compounds(Aniline, TNT)

LIST OF PRACTICALS:
1. Purify the given organic compounds by distillation.
2. Purify the given organic compounds by recrystillazation.
3. Introduction to the use of stereo models.
4.Synthesis, Purification, Characterization (by using Solubility, Melting Point,T.L.C. and percentage purity) of organic compounds and percent yield calculations of the following compounds:
a) 2, 4, 6-trinitro phenol (Picric acid) from phenol
b) Iodoform from ethyl alcohol
c) 2, 4, 6-tribromoaniline from aniline
d) 2, 4, 6-tribromo phenol from phenol
e) Phenylbutazone from phenol
f) Benzanilide from aniline
g) Phthalidimide from phthalic anhydride
h) Thiourea
i) Phenyl urea
j) Flourescein
k) Methly orange
l) Methly red

BOOKS RECOMMENDED:
1. Organic Chemistry, R.T. Morrison and R.N. Boyd, 6th Edition, New York.
2. Organic Chemistry, T.W.G. Solomons, 8th Edition, John Wiley & Sons, Inc
3. Advanced Organic Chemistry, J. March, Reaction Mechanisms and Structure, John Wiley and Sons, N.Y.
4. Mechanisms and structure in Organic Chemistry, E.S. Gould, Hold Rinchart and Winston, New York.
5. Advanced Organic Chemistry, Reaction Mechanisms, Bernard Miller, 2nd edition, Pearson education Ptc. Ltd. Singapore.
6. Named Organic Reactions, Thomas Lane & Andreas Plagens, 2nd edition, John Wiley and Sons, N.Y).
7. Organic Chemistry Finar Vol-1 & 2.
8. Structure and Mechanism in Organic Chemistry, Ingold, C. K., Cornell University.
9. Stereochemistry of Carbon Compounds, Eliel, E.L., McGraw Hill, New York.
10. Elements of Stereochemistry, Eliel, E.L., Wiley, New York.